The Yashidine 5 (Procyclidine hydrochloride) is a synthetic antispasmodic compound with low toxic chemical composition. It helps to cure symptomatic treatment of Parkinsonism (paralysis agitans) and extrapyramidal dysfunction that is caused by tranquilizer therapy.
Procyclidine hydrochloride is water-soluble, tasteless and white crystalline substance that is chemically abbreviated as α-cyclohexyl-α-phenyl-1-pyrrolidinepropanol hydrochloride. The tablets can be consumed orally as per the prescription of doctor. It is available in the market under the hydrochloride.
| Composition: |
- Each uncoated tablet contains: procyclidine hydrochloride BP 5 mg
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| Category: |
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| Pharmacology: |
- Procyclidine hydrochloride has an atropine-like action and exerts
an antispasmodic effect on smooth muscle. It is potent mydriatic and
inhibits salvation. It has no sympathetic ganglion-blocking activity
in doses as high as 4 mg/kg as measured by the lack of inhibition of
the response of the nictitating membrane to preganglionic electrical
stimulation.
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| Indications: |
- Yashidine 5 is indicated in the treatment of parkinsonism
including the post- encephalitic, arteriosclerotic and idiopathic
types. Partial control of the Parkinsonism symptoms is usual
therapeutic accomplishment. Procyclidine hydrochloride is usually
more efficacious in the relief of rigidity than tremor, but tremor,
fatigue, weakness and sluggishness are frequently beneficially
influenced. It can be substituted for all the previous medications
in mild and moderate cases. For the control of more severe cases,
other drugs may be added to procyclidine therapy as indications
warrant.
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| Contraindications: |
- Procyclidine Hydrochloride should not be used in angle-closure
glaucoma although simple type glaucomas do not appear to be
adversely affected.
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| Adverse effects: |
- Adverse reactions include dryness of mouth, mydriasis, blurring
of vision, giddiness, lightheadedness and gastrointestinal
disturbances such as nausea, vomiting, epigastric distress and
constipation. Occasionally an allergic reaction such as skin rash
may occur. Felling of muscular weakness may occur.
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| Dosage & administration: |
- The usual dose of yashidine 5 for initial treatment is 2.5 mg
administered three times daily after meals. If well tolerated, this
dose may be gradually increased to 5 mg three times a day. In most
cases excellent results may be obtained with 10 to 20 mg daily.
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| Presentation: |
- 10 tablets packed in blister pack.
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