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Epinephrine Injections

By maintaining quality standards and precise composition, we bring forth Yashiadrine injection (Epinephrine Injections) that is extremely safe in nature and is non toxic. The injection is offered with 1 mg capacity and maintains set health standards of the industry. It is extremely safe in nature and all the chemicals are processed in a hygienic environment and is delivered with tamper-proof packaging in order to maintain quality parameters. Yashiadrine injection is given for the treatment of cardiac emergencies and brief medical history should be considered prior the prescription.

Composition:	Each mL contains: epinephrine acid tartrate BP, Eq. to epinephrine BP 1 mg, water for injection q s
Category:	Adrenoceptor agonist
Method of action:	Epinephrine acts on both alpha and beta receptor sites of sympathetic effector cells. At usual dosage, most prominent actions are on beta receptors of heart, vascular and other smooth muscle. At high doses, alpha adrenergic effects predominate.
Pharmacokinetics:	It crosses the placenta but not the blood-brain barrier. The parenteral action is terminated by uptake into adrenergic neurons. It is metabolized by MAO and COMT. On Set of Action: IV dose: Immediate, SC Dose: 5 to 10 minutes
Indication and usage:	Restoration of cardiac rhythm in cardiac arrest in the absence of ventricular fibrillation (intracardiac injection), attacks of transitory AV block and syncopal seizures (strokes - Adams syndrome), anaphylactic shock e.g. from insect bites, drugs, hypersensitivity reactions, haemostatic, to treat mucosal congestion of rhinitis and acute sinusitis, to relieve bronchial asthmatic paroxysms, urticaria, angionerotic oedema.
Dosage & administration:	Cardiac arrest: 0.5 to 1 mg (5 to 10 mL of 1:10000 solution) diluted to 10 mL with NaCl administered IV or intracardiac to restore myocardial contractility. During a resuscitation effort administer 0.5 to 1 mg by IV every 5 minutes. If IV access is not available the drug may be injected via the endotracheal tube. Perform 5 rapid insufflations forcefully expel 10 mL containing 1 mg epinephrine (0.1 mg/mL) directly into the tube follow with 5 quick insufflations. Hypersensitivity reactions bronchial asthma, urticaria, anaphylactic shock: Use SC Adults: IV dose 0.1 to 0.25 mg injected slowly. Neonates: 0.01 mg/Kg Infants: 0.05 mg initial dose repeated at 20 to 30 minutes intervals in the management of asthma attacks. Concomitant administration with local anaesthetics: epinephrine 1:200,000 is the usual concentration employed with local anaesthetics to delay absorption of drugs. Intraspinal use: 0.2 to 0.4 mL of 1: 2000 solutions added to anaesthetic spinal fluid mixture to prolong anaesthetic action by limiting absorption. Dose for resuscitation of neonates & children: 0.1 mL/Kg of 1: 10000 dilution solution by IV
Contraindication:	Hypersensitivity, narrow angle glaucoma, non-anaphylactic shock, anaesthesia of extremities, shock during general anaesthesia in labour because it may delay the second stage, in cardiac dilatation and coronary insufficiency, to counteract circulatory collapse or hypotension due to phenothiazines, since such agents may reverse pressor effect of epinephrine leading to a further lowering of blood pressure.
Adverse effect:	Cardiac arrhythmias and excessive rise in BP may occur. Angina may occur in patients with CAD, Anxiety, tremor, tachycardia, headache, cold extremities.
Special precautions:	Cardiovascular disease, hypertension, diabetes, hyperthyroidism, psychoneurotic individuals, thyrotoxicosis.
Drug interactions:	Beta blockers: concomitant administration may block beta adrenergic effects of epinephrine causing hypertension. Cardiac glycosides: may make cardiac arrhythmias more likely. Ergot alkaloids and phenothiazines: May reserve the pressor effects of epinephrine. Antihistamines: pressor effects may be potentiated. Halogenated hydrocarbon anaesthetics: sensitize the myocardium to the effects of ? catecholamines leading to serious arrhythmias. Oxytoxic drugs: may cause severe persistent hypertension. Sympathomimetic drugs: additive effects and increased toxicity. May induce serous cardiac arrhythmias. Tricyclic antidepressants: pressor may be potentiated.
Storage:	Store between temperatures 8℃ to 25℃. Protect from light. Keep out of reach of children.
Presentation:	10 Ampoules of 1 mL in a plastic tray and each tray packed in a printed carton.

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