| Dosage & administration: |
- As directed by the physician.
- Take Yashither tablets orally with meal.
- Adult Dosage: Take first dose of 4 tablets as a single
initial dose, as soon as possible after malaria is diagnosed. Take
the second dose of 4 tablets after 8 hours after first dose. Take
the third dose of 4 tablets after 24 hours after first dose. Take
the fourth dose of 4 tablets after 36 hours after the first dose.
Take the fifth dose of 4 tablets after 48 hours after the first
dose. Take the sixth dose of 4 tablets after 60h after the first
dose. (Total course of 24 tablets)
| Total Dosage |
Total Tablets |
Therapy regime (Tablets) |
| Day 1 |
Day 2 |
Day 3 |
| 0 h |
8 h |
24 h |
36 h |
48 h |
60 h |
| 6 |
24 |
4 |
4 |
4 |
4 |
4 |
4 |
- Children dosage: The dosage for children is based on
their body weight.
| Body Weight (Kg) |
Total Tablets |
Therapy regime (Tablets) |
| Day 1 |
Day 2 |
Day 3 |
| 0 h |
8 h |
24 h |
36 h |
48 h |
60 h |
| 10 - 15 |
6 |
1 |
1 |
1 |
1 |
1 |
1 |
| 15 - 25 |
12 |
2 |
2 |
2 |
2 |
2 |
2 |
| 25 - 35 |
18 |
3 |
3 |
3 |
3 |
3 |
3 |
| > 35 |
24 |
4 |
4 |
4 |
4 |
4 |
4 |
| Contra-indications: |
- Hypersensitivity to any ingredient of the yashither
- Patients with complicated malaria
- Patients with a family history of sudden death of congenital
prolongation of the Qtc interval on electrocardiograms or with any
other clinical conditions known to prolong the Qt interval
- Patients with disturbances of electrolyte balance e.g.
hypokalemia or hypomagnesemia
- Patients who are taking drug which is metabolizes by the
cytochrome enzyme CYP2D6 (e. g. flecainide, metoprolol, imipramine,
amitryptyline, clomipramine)
- Patients that are known to prolong the Qt interval
These drugs include:
- Antiarrhythmics of class IA and III
- Neuroleptics, antidepressive agents
- Certain antibiotics including some agents of the following
classes: macrolides, fluroquinolones, imidazole and trazole
antifungal agents
- Certain non-sedating antihistamines (terfenadine, astemizole)
- Cisapride
|
| Precautions: |
- Do not take this as a preventive against malaria
- Do not use this to treat malaria that affects the brain
- Pregnancy and lactation
|
| Side effects: |
- CNS: Headaches, dizziness and fatigue, sleep disorder
- Cardiovascular system tachycardia
- Muscles and bones: aching muscles and joints
- Alimentary tracts: nausea, vomiting, diarrhea, stomach
pain, loss of appetite
- Allergy: skin itch or erythema
- Discontinue the medication and inform your doctor about side
effects when using this medicine.
|
| Interactions: |
- Avoid concomitant administration with antioxidant agents such as
vitamin E, vitamin C, glutathione because of possible diminution of
antimalarial action
- Artemether may potentiate other antimalarial activity
- As grapefruit juice inhibits the metabolism of some drugs via the
CYP3A4 cytochrome enzyme. It is advisable not to drink grapefruit
juice while taking yashither.
|
| Presentation: |
- 24 tablets in blister packed monocarton along with leaflet.
|
| Storage: |
- Store in a cool & dry place
- Always keep out of reach of children
|
| Note: |
- Read the directions carefully before use
- For any information please refer to your doctor
|
|
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